Asset profile

Tisotumab Vedotin Humax-tf-adc

Antibody–drug conjugate

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Approvedregulatory verdict

Evidence outlook

Approved: Cervical Cancer

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

Also in development:Non-Small Cell Lung Cancer · Phase 2

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Competitive landscape

63 competitors in this universe: 1 direct rival (same mechanism and indication), 0 same-class, 62 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Tisotumab Vedotin Humax-Tf-Adc: this drugApprovedAntibody–drug conjugateTissue Factor (TF)
STRO-004Phase 1Antibody–drug conjugateTissue Factor (TF)
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
BrigatinibApprovedSmall moleculeALK
CapmatinibApprovedSmall moleculeMET
CemiplimabApprovedMonoclonal antibodyPD-1
CeritinibApprovedSmall moleculeALK

…and 48 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(2 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2028 (1)
December 2028 (1)
Phase 4Cervical CancerRecruiting
Est. primary completion 2028-12-13 · NCT06952660 · CT.gov ↗
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2029 (1)
March 2029 (1)
Phase 2Vulvar Carcinoma, Recurrent or Metastatic Vulvar Cancer, Squamous Cell Carcinoma VulvaNot yet recruiting
Est. primary completion 2029-03 · NCT07672782 · CT.gov ↗
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All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (1)
Phase 2 (5)
Phase 1/2 (4)
Phase 1 (1)
Phase 4 (1)
Used as active comparator (1)