Asset profile
Risvodetinib (IkT-148009)
Small molecule
Evidence outlook · results not reported
NCT05424276 · Parkinson Disease
The lead study's design has limits that temper confidence (see the rationale below), and its results have not been reported. This tier describes the design, not an outcome.
NCT05424276: The trial was well designed - randomized, blinded, and placebo-controlled with roughly 33-35 patients per arm - but its designated primary endpoint was adverse-event incidence rather than a disease-related clinical outcome, and no statistical comparison across arms was reported for that primary endpoint (event rates were similar across all four groups: 54-64%). The efficacy-related measures (MDS-UPDRS, PDQ-39, etc.) were only secondary and the study was explicitly stated as not powered to detect efficacy differences, with results showing no consistent separation from placebo.
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Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
61 competitors in this universe: 1 direct rival (same mechanism and indication), 0 same-class, 60 same-indication; 39 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Risvodetinib (IkT-148009): this drug | Phase 2 | Small molecule | c-Abl | ||
| FB-101 | Phase 1 | Small molecule | c-Abl | ||
| Amantadine ER (Gocovri / ADS-5102) | Approved | Small molecule | NMDA receptor | ||
| Apomorphine (Apokyn) | Approved | Small molecule | dopamine | ||
| Apomorphine Sublingual Film (Kynmobi) | Approved | Small molecule | dopamine | ||
| Crexont (IPX203) | Approved | Small molecule | dopamine precursor | ||
| Entacapone (Comtess) | Approved | Small molecule | COMT | ||
| Foslevodopa / Foscarbidopa (Vyalev) | Approved | Small molecule | dopamine precursor | ||
| Inbrija (CVT-301) | Approved | Small molecule | dopamine precursor | ||
| Istradefylline (Nourianz) | Approved | Small molecule | adenosine A2A | ||
| Levodopa-Carbidopa Intestinal Gel (Duopa) | Approved | Small molecule | dopamine precursor | ||
| Opicapone (Ongentys) | Approved | Small molecule | COMT, PDE4 | ||
| Parcopa | Approved | Small molecule | dopamine precursor | ||
| Pimavanserin (Nuplazid) | Approved | Small molecule | 5-HT2A/2C receptor, Serotonin 5-HT2A receptor (antagonist / inverse agonist) | ||
| Pramipexole (Sifrol/Mirapex) | Approved | Small molecule | Dopamine D2/D3 receptors | ||
| Pramipexole ER (Mirapex ER) | Approved | Small molecule | Dopamine D2 / D3 receptors |
…and 46 more. Research shows the complete landscape.
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Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.