Asset profile
Opicapone · Ongentys
Small molecule
Evidence outlook
Approved: Parkinson's Disease
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
track record: Partial signal
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
71 competitors in this universe: 2 direct rivals (same mechanism and indication), 9 same-class, 60 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Opicapone (Ongentys): this drug | Approved | Small molecule | PDE4, COMT | ||
| Entacapone (Comtess) | Approved | Small molecule | COMT | ||
| Trigel (Lecigon) | Phase 1 | Small molecule | COMT | ||
| Apremilast (Otezla) | Approved | Small molecule | PDE4 | ||
| Crisaborole (Eucrisa) | Approved | Small molecule | PDE4 | ||
| Difamilast (Moizerto / Adquey) | Approved | Small molecule | PDE4 | ||
| Roflumilast (Zoryve) | Approved | Small molecule | PDE4 | ||
| Hemay005 | Phase 3 | Small molecule | PDE4 | ||
| HPP737 | Phase 3 | Small molecule | PDE4 | ||
| ALTO-101 | Phase 2 | Small molecule | PDE4 | ||
| PALI-2108 | Phase 2 | Small molecule | PDE4 | ||
| PF-07038124 | Phase 2 | Small molecule | PDE4 | ||
| Amantadine ER (Gocovri / ADS-5102) | Approved | Small molecule | NMDA receptor | ||
| Apomorphine (Apokyn) | Approved | Small molecule | dopamine | ||
| Apomorphine Sublingual Film (Kynmobi) | Approved | Small molecule | dopamine | ||
| Crexont (IPX203) | Approved | Small molecule | dopamine precursor |
…and 56 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.