Asset profile

Recombinant human growth hormone

Biologic (subtype unspecified)

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Partialsignal

Evidence outlook · lead readout

NCT03535415 · Dwarfism

The completed lead evidence is positive, with design limits that temper confidence; the rationale below says which.

NCT03535415: Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.

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Competitive landscape

61 competitors in this universe: 0 direct rivals (same mechanism and indication), 1 same-class, 60 same-indication; 26 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Recombinant Human Growth Hormone: this drugPhase 3Biologic (subtype unspecified)Growth hormone receptor
Somatropin (Serostim)ApprovedProtein / enzyme therapeuticGrowth hormone receptor
Atrasentan (Vanrafia)ApprovedSmall moleculeEndothelin A receptor
Avacopan (Tavneos)ApprovedSmall moleculeComplement C5a receptor 1 (C5aR1/CD88)
Baxdrostat (Baxfendy)ApprovedSmall moleculeAldosterone synthase (CYP11B2)
Budesonide (targeted-Release) (TARPEYO / Nefecon)ApprovedSmall moleculeGlucocorticoid receptor
Canagliflozin (Invokana)ApprovedSmall moleculeSGLT2
Dapagliflozin (Farxiga / Forxiga)ApprovedSmall moleculeSGLT2
Daprodustat (Jesduvroq)ApprovedSmall moleculeHIF prolyl hydroxylase (HIF-PH1/2/3)
Difelikefalin (Korsuva)ApprovedPeptideKappa-opioid receptor (agonist, peripherally restricted)
Empagliflozin (Jardiance)ApprovedSmall moleculeSGLT2
Etelcalcetide (Parsabiv)ApprovedPeptideCalcium-sensing receptor (CaSR), allosteric agonist on parathyroid chief cells
Extended-Release Calcifediol (Rayaldee)ApprovedSmall moleculeVitamin D receptor (VDR), via conversion to calcitriol
Ferric Carboxymaltose (Injectafer / Ferinject)ApprovedIron Complex (iv)Iron repletion
Ferric Derisomaltose (Monoferric / Monofer)ApprovedIron Complex (iv)Iron repletion
Ferric Pyrophosphate Citrate (Triferic)ApprovedSmall moleculeIron-replacement therapy delivered via dialysate

…and 46 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(3 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 2Gulf War Syndrome, Adult Growth Hormone DeficiencyRecruiting
Est. primary completion 2026-12 · NCT05355272 · CT.gov ↗
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2027 (1)
September 2027 (1)
Phase 4Acute Brain Injuries, Moderate to Severe Traumatic Brain InjuryNot yet recruiting
Est. primary completion 2027-09-30 · NCT07481656 · CT.gov ↗
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2028 (1)
July 2028 (1)
Phase 1/2Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)Active not recruiting
Est. primary completion 2028-07 · NCT07036003 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (8)
Phase 2 (15)
Phase 1/2 (5)
Phase 1 (1)
Phase 4 (10)
Early phase / not applicable (3)
Used as active comparator (6)
Appears in other studies (34)