Asset profile

SHR-A2102

Antibody–drug conjugate

Phase 3Nectin-4No featureable registry evidence
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—no evidence

Evidence outlook

No featureable registry evidence

The studies registered under this drug are withdrawn, terminated, post-marketing only, or belong to other products, so none can represent its own clinical progression.

Also in development:Non-Small Cell Lung Cancer · Phase 2

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Competitive landscape

120 competitors in this universe: 5 direct rivals (same mechanism and indication), 0 same-class, 115 same-indication; 82 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
SHR-A2102: this drugPhase 3Antibody–drug conjugateNectin-4
Enfortumab VedotinPhase 3Antibody–drug conjugateNectin-4
Zelenectide PevedotinPhase 2PeptideNectin-4
225Ac-AKY-1189Phase 1RadiopharmaceuticalNectin-4
IPH4502Phase 1Antibody–drug conjugateNectin-4
LY4052031Phase 1Antibody–drug conjugateNectin-4
Abemaciclib (Verzenio)ApprovedSmall moleculeCDK4 and CDK6
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alpelisib (BYL719)ApprovedSmall moleculePI3K-alpha
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AnastrozoleApprovedSmall moleculeAromatase
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR

…and 105 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(14 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (3)
December 2026 (3)
Phase 2Advanced Malignant TumourRecruiting
Est. primary completion 2026-12 · NCT06915142 · CT.gov ↗
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Phase 2TNBC - Triple-Negative Breast CancerNot yet recruiting
Est. primary completion 2026-12-31 · NCT06819319 · CT.gov ↗
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Phase 2Triple-negative Breast CancerRecruiting
Est. primary completion 2026-12-31 · NCT05076682 · CT.gov ↗
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2027 (6)
March 2027 (3)
Phase 1/2Recurrent/Metastatic Head and Neck Squamous Cell CarcinomaRecruiting
Est. primary completion 2027-03 · NCT07059221 · CT.gov ↗
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Phase 2HR+/HER2- Metastatic Breast CancerRecruiting
Est. primary completion 2027-03 · NCT06433609 · CT.gov ↗
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Phase 2Pancreatic CancerRecruiting
Est. primary completion 2027-03 · NCT06547736 · CT.gov ↗
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April 2027 (1)
Phase 1Lung CancerNot yet recruiting
Est. primary completion 2027-04-30 · NCT07414953 · CT.gov ↗
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May 2027 (1)
Phase 1/2Advanced Urothelial CarcinomaRecruiting
Est. primary completion 2027-05-31 · NCT06639347 · CT.gov ↗
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December 2027 (1)
Phase 3Recurrent Cervical Cancer, Metastatic Cervical CancerRecruiting
Est. primary completion 2027-12 · NCT07418749 · CT.gov ↗
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2028 (3)
January 2028 (1)
Phase 3Locally Advanced or Metastatic Urothelial CarcinomaRecruiting
Est. primary completion 2028-01-31 · NCT07393542 · CT.gov ↗
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October 2028 (1)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-10 · NCT07175220 · CT.gov ↗
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December 2028 (1)
Phase 2Advanced Solid TumorsRecruiting
Est. primary completion 2028-12 · NCT06895928 · CT.gov ↗
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2031 (2)
December 2031 (2)
Phase 2/3Muscular Invasive Bladder Cancer (MIBC)Recruiting
Est. primary completion 2031-12 · NCT06879145 · CT.gov ↗
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Phase 1/2Advanced Solid TumorsRecruiting
Est. primary completion 2031-12-31 · NCT06417554 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (3)
Phase 2/3 (1)
Phase 2 (12)
Phase 1/2 (7)
Phase 1 (3)