Asset profile

INCB123667

Small molecule

Phase 3Mechanism not established
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Phase 3underway

Evidence outlook · registrational

Ovarian Cancer: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2028-11-15.

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Competitive landscape

12 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 12 same-indication; 4 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
INCB123667: this drugPhase 3Small molecule—
AvutometinibApprovedSmall moleculeRAF/MEK, MEK1/2 and RAF (CRAF, BRAF)
DefactinibApprovedSmall moleculeFAK
NiraparibApprovedSmall moleculePARP1/2
Relacorilant (Lifyorli)ApprovedSmall moleculeGlucocorticoid receptor
Olvimulogene NanivacirepvecPhase 3Oncolytic VirusNo discrete molecular target
Rina-SPhase 3Small moleculeFolate receptor alpha (FRα)
Luveltamab TazevibulinPhase 2/3Antibody–drug conjugate—
BirinapantPhase 2——
StenoparibPhase 2Small molecule—
COM701Phase 1Small molecule—
IDE-161Phase 1Small moleculePARG
XmAb541Phase 1Multispecific antibody—
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(5 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (3)
January 2027 (1)
Phase 1Renal ImpairmentRecruiting
Est. primary completion 2027-01-04 · NCT07559396 · CT.gov ↗
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April 2027 (2)
Phase 1Hepatic Insufficiency, Liver DiseasesRecruiting
Est. primary completion 2027-04-13 · NCT07559474 · CT.gov ↗
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Phase 2Ovarian CancerRecruiting
Est. primary completion 2027-04-27 · NCT07023627 · CT.gov ↗
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2028 (1)
November 2028 (1)
Phase 3Ovarian CancerRecruiting
Est. primary completion 2028-11-15 · NCT07214779 · CT.gov ↗
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2032 (1)
May 2032 (1)
Phase 3Ovarian CancerNot yet recruiting
Est. primary completion 2032-05-01 · NCT07797283 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (2)
Phase 2 (1)
Phase 1 (4)
Appears in other studies (1)