Asset profile

Balipodect (TAK-063)

Small molecule

Phase 3Phosphodiesterase 10A (PDE10A)No recent registered activity
Negativelead readout

Evidence outlook · lead readout

NCT02477020 · Schizophrenia

The lead readout missed its primary endpoint. The grade and rationale below record what the trial was designed to show and what it found.

NCT02477020: The study randomly assigned 164 participants to TAK-063 or placebo and used quadruple blinding of participants, care providers, investigators, and outcome assessors. The clinical primary endpoint was the change in PANSS total score at week 6; TAK-063 showed a larger numerical improvement than placebo, but the difference was not statistically significant (p=0.115), supporting moderate rather than strong evidence.

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