Asset profile
Dexmedetomidine · Igalmi
Unknown / undisclosed
Approved / Phase 4Mechanism not established
Approvedregulatory verdict
Evidence outlook
Approved: Schizophrenia, Bipolar Disorder
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
Also in development:Alzheimer's Disease Agitation
Featured evidence outside covered markets:NCT00398827 · Anesthesia · Phase 3 · completed · ungraded
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
62 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 62 same-indication.
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| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Dexmedetomidine (Igalmi): this drug | Approved | — | — | ||
| Aripiprazole (Abilify Maintena) | Approved | Small molecule | Dopamine D2 and serotonin 5-HT1A receptors (partial agonist), Dopamine D2/D3 and serotonin 5-HT1A receptor, Dopamine D2 receptor (partial agonist) | ||
| Aripiprazole (Abilify MyCite) | Approved | Combination | Dopamine D2 and serotonin 5-HT1A receptors (partial agonist); serotonin 5-HT2A receptor (antagonist) | ||
| Aripiprazole (Abilify) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Aripiprazole Lauroxil (Aristada Initio) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Aripiprazole Lauroxil (Aristada) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Asenapine | Approved | Small molecule | Dopamine D2 and serotonin 5-HT2A receptors (antagonist) | ||
| Brexpiprazole (Rexulti) | Approved | Small molecule | Dopamine D2/D3 and serotonin 5-HT1A receptor | ||
| Cariprazine (Vraylar) | Approved | Small molecule | Dopamine D3/D2 receptor (partial agonist) | ||
| Clozapine | Approved | Small molecule | Dopamine D2 and serotonin 5-HT2A receptors (antagonist) | ||
| Dexmedetomidine (Igalmi) | Approved | Small molecule | Alpha-2 adrenergic receptor (agonist) | ||
| Dextromethorphan / Bupropion (Auvelity) | Approved | Small molecule | sigma-1/NMDA | ||
| Fazaclo | Approved | Small molecule | Dopamine D2 and serotonin 5-HT2A receptors (antagonist) | ||
| Haloperidol | Approved | Small molecule | Dopamine D2 receptor (antagonist) | ||
| Iloperidone (PD Psychosis Use) (Fanapt) | Approved | Small molecule | Dopamine D2 and serotonin 5-HT2A receptors (antagonist) | ||
| Loxapine (Adasuve) | Approved | Small molecule | Dopamine D2 and serotonin 5-HT2A receptors (antagonist) |
…and 47 more. Research shows the complete landscape.
Research
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
(84 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (24)
October 2026 (4)
Phase 1Sedation and AnalgesiaRecruiting
Est. primary completion 2026-10-22 · NCT07669012 · CT.gov ↗
What to watch
Phase 1Caudal Block for Postoperative AnalgesiaNot yet recruiting
Est. primary completion 2026-10-30 · NCT06668220 · CT.gov ↗
What to watch
Phase 3Medical ThoracoscopyRecruiting
Est. primary completion 2026-10-31 · NCT07184801 · CT.gov ↗
What to watch
Phase 4Thyroid DiseasesRecruiting
Est. primary completion 2026-10-31 · NCT07462195 · CT.gov ↗
What to watch
November 2026 (8)
Phase 3Cough SuppressionNot yet recruiting
Est. primary completion 2026-11-01 · NCT07213037 · CT.gov ↗
What to watch
Phase 4VaricocelectomyNot yet recruiting
Est. primary completion 2026-11-01 · NCT07214701 · CT.gov ↗
What to watch
Phase 4Abdominal Cancer SurgeriesNot yet recruiting
Est. primary completion 2026-11-01 · NCT07214714 · CT.gov ↗
What to watch
Phase 1Aki After Ascending Aortic SurgeriesActive not recruiting
Est. primary completion 2026-11-02 · NCT06958367 · CT.gov ↗
What to watch
Early phase / not applicablePressor ResponseNot yet recruiting
Est. primary completion 2026-11-15 · NCT07164326 · CT.gov ↗
What to watch
Early phase / not applicableAnalgesiaRecruiting
Est. primary completion 2026-11-25 · NCT05851768 · CT.gov ↗
What to watch
Phase 4Emergence AgitationNot yet recruiting
Est. primary completion 2026-11-30 · NCT07601698 · CT.gov ↗
What to watch
Early phase / not applicableHip OsteoarthritisNot yet recruiting
Est. primary completion 2026-11-30 · NCT07743853 · CT.gov ↗
What to watch
December 2026 (12)
Phase 4Abdominal Cancer SurgeryNot yet recruiting
Est. primary completion 2026-12-01 · NCT06695468 · CT.gov ↗
What to watch
Early phase / not applicableHemodynamic Effect, Dexmedetomidine, Magnesium Sulphate, Lidocaine, Peribulbar Block, Dacryocystorhinostomy, General AnesthesiaRecruiting
Est. primary completion 2026-12-01 · NCT07675616 · CT.gov ↗
What to watch
Early phase / not applicablePostoperative Nausea and VomitingRecruiting
Est. primary completion 2026-12-01 · NCT07271147 · CT.gov ↗
What to watch
Early phase / not applicableDexmedetomidine Analgesia, Knee SurgeryEnrolling by invitation
Est. primary completion 2026-12-30 · NCT07131579 · CT.gov ↗
What to watch
Phase 1Regional AnaesthesiaNot yet recruiting
Est. primary completion 2026-12-31 · NCT07279727 · CT.gov ↗
What to watch
Phase 2Acute Anxiety StatesRecruiting
Est. primary completion 2026-12-31 · NCT07550881 · CT.gov ↗
What to watch
Phase 2/3Major Abdominal Surgery, Postoperative Delirium (POD), Sleep Disturbances, Intranasal DexmedetomidineNot yet recruiting
Est. primary completion 2026-12-31 · NCT07538284 · CT.gov ↗
What to watch
Phase 4Renal Transplantation, DexmedetomidineNot yet recruiting
Est. primary completion 2026-12-31 · NCT05935293 · CT.gov ↗
What to watch
Phase 4Consciousness, Level AlteredRecruiting
Est. primary completion 2026-12-31 · NCT07145697 · CT.gov ↗
What to watch
Phase 4Post-stroke DepressionNot yet recruiting
Est. primary completion 2026-12-31 · NCT07739329 · CT.gov ↗
What to watch
Early phase / not applicablePostoperative Pain, Analgesia, Supratentorial Brain TumorNot yet recruiting
Est. primary completion 2026-12-31 · NCT06406829 · CT.gov ↗
What to watch
Early phase / not applicableColorectal NeoplasmsRecruiting
Est. primary completion 2026-12-31 · NCT07239479 · CT.gov ↗
What to watch
2027 (46)
January 2027 (12)
Early phase / not applicableAnalgesiaActive not recruiting
Est. primary completion 2027-01 · NCT07683416 · CT.gov ↗
What to watch
Phase 2Familial DysautonomiaEnrolling by invitation
Est. primary completion 2027-01-01 · NCT06148311 · CT.gov ↗
What to watch
Early phase / not applicableAnkle Disease, Foot DiseasesRecruiting
Est. primary completion 2027-01-01 · NCT07289620 · CT.gov ↗
What to watch
Early phase / not applicableHip OsteoarthritisRecruiting
Est. primary completion 2027-01-01 · NCT07330999 · CT.gov ↗
What to watch
Early phase / not applicableKnee OsteoarthritisRecruiting
Est. primary completion 2027-01-01 · NCT07386600 · CT.gov ↗
What to watch
Early phase / not applicablePostpartum Depression (PPD)Not yet recruiting
Est. primary completion 2027-01-01 · NCT07501728 · CT.gov ↗
What to watch
Early phase / not applicableAnalgesia Assessment, Above Knee Amputation, Fentanyl vs DexmedetomidineRecruiting
Est. primary completion 2027-01-01 · NCT07640516 · CT.gov ↗
What to watch
Phase 3Cerebral Desaturation Events, Spine SurgeriesNot yet recruiting
Est. primary completion 2027-01-20 · NCT06848595 · CT.gov ↗
What to watch
Early phase / not applicablePainRecruiting
Est. primary completion 2027-01-25 · NCT07174440 · CT.gov ↗
What to watch
Phase 4Opioid Free AnesthesiaRecruiting
Est. primary completion 2027-01-30 · NCT07389096 · CT.gov ↗
What to watch
Early phase / not applicableHip Osteoarthritis, Arthropathy of HipRecruiting
Est. primary completion 2027-01-31 · NCT07327372 · CT.gov ↗
What to watch
Early phase / not applicableKnee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II PatientsNot yet recruiting
Est. primary completion 2027-01-31 · NCT07736352 · CT.gov ↗
What to watch
February 2027 (3)
Phase 4Lower Limb Orthopedic SurgeryNot yet recruiting
Est. primary completion 2027-02 · NCT07300826 · CT.gov ↗
What to watch
Phase 4Laparoscopic Cholecystectomy SurgeryNot yet recruiting
Est. primary completion 2027-02 · NCT07425444 · CT.gov ↗
What to watch
Early phase / not applicableAnesthesiaActive not recruiting
Est. primary completion 2027-02 · NCT07271459 · CT.gov ↗
What to watch
March 2027 (4)
Phase 4General Anesthesia, Surgery, Dexmedetomidine, Esketamine, Quality of RecoveryRecruiting
Est. primary completion 2027-03 · NCT07308756 · CT.gov ↗
What to watch
Phase 1Sleep, Delirium, ICU HospitalizationNot yet recruiting
Est. primary completion 2027-03-01 · NCT06824077 · CT.gov ↗
What to watch
Early phase / not applicableChronic MigraineRecruiting
Est. primary completion 2027-03-01 · NCT07769255 · CT.gov ↗
What to watch
April 2027 (4)
Phase 4Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, EsketamineRecruiting
Est. primary completion 2027-04 · NCT06399185 · CT.gov ↗
What to watch
Early phase / not applicableAnesthesia, Anesthesia Complication, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity, Feasibility Studies …Active not recruiting
Est. primary completion 2027-04 · NCT06884540 · CT.gov ↗
What to watch
Early phase / not applicableIntraoperative Infusion, Lidocaine, Dexmedetomidine, Cerebral Oxygen Saturation, Postoperative Delirium, Elderly Patients …Recruiting
Est. primary completion 2027-04-01 · NCT07108764 · CT.gov ↗
What to watch
Phase 4Sevoflurane Agitiion in PediatricNot yet recruiting
Est. primary completion 2027-04-10 · NCT06734195 · CT.gov ↗
What to watch
May 2027 (3)
Early phase / not applicableAnesthesiaActive not recruiting
Est. primary completion 2027-05 · NCT07105618 · CT.gov ↗
What to watch
Phase 3Ventricular Tachycardia, Ventricular Arrhythmias, Ventricular Fibrillation, Recurrent Ventricular TachycardiaRecruiting
Est. primary completion 2027-05-08 · NCT06281977 · CT.gov ↗
What to watch
Early phase / not applicableNew Onset, Atrial FibrillationNot yet recruiting
Est. primary completion 2027-05-31 · NCT07482540 · CT.gov ↗
What to watch
June 2027 (5)
Phase 4Postoperative Pain ManagementRecruiting
Est. primary completion 2027-06 · NCT07316166 · CT.gov ↗
What to watch
Early phase / not applicableIntrapartum FeverNot yet recruiting
Est. primary completion 2027-06-01 · NCT07501221 · CT.gov ↗
What to watch
Phase 3Breast CancerRecruiting
Est. primary completion 2027-06-06 · NCT05439005 · CT.gov ↗
What to watch
Phase 4Chronic Post-Surgical PainEnrolling by invitation
Est. primary completion 2027-06-30 · NCT06849466 · CT.gov ↗
What to watch
Early phase / not applicableDepth of Anesthesia Monitoring, BIS-EEGNot yet recruiting
Est. primary completion 2027-06-30 · NCT07699523 · CT.gov ↗
What to watch
July 2027 (4)
Phase 2Spinal Fusion, Adolescent Idiopathic ScoliosisEnrolling by invitation
Est. primary completion 2027-07 · NCT06067893 · CT.gov ↗
What to watch
Phase 3Rib FracturesRecruiting
Est. primary completion 2027-07-01 · NCT04928300 · CT.gov ↗
What to watch
Phase 2Anesthesia, Pediatric SurgeryRecruiting
Est. primary completion 2027-07-03 · NCT06736483 · CT.gov ↗
What to watch
Early phase / not applicableNeurosurgery, Brain Cancer, MeningiomaNot yet recruiting
Est. primary completion 2027-07-22 · NCT07398066 · CT.gov ↗
What to watch
September 2027 (2)
October 2027 (1)
November 2027 (3)
Phase 1AnesthesiaNot yet recruiting
Est. primary completion 2027-11 · NCT05619627 · CT.gov ↗
What to watch
Phase 3Effects of Dexmedetomidine & Magnesium Sulphate on Patients Undergoing DHSNot yet recruiting
Est. primary completion 2027-11-01 · NCT07326397 · CT.gov ↗
What to watch
Phase 4Behavior ProblemNot yet recruiting
Est. primary completion 2027-11-30 · NCT07570160 · CT.gov ↗
What to watch
December 2027 (5)
Phase 4Postoperative Pain Management in Total Knee ArthroplastyNot yet recruiting
Est. primary completion 2027-12 · NCT07176065 · CT.gov ↗
What to watch
Phase 3PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical VentilationRecruiting
Est. primary completion 2027-12-30 · NCT06878703 · CT.gov ↗
What to watch
Phase 4Respiratory InsufficiencyNot yet recruiting
Est. primary completion 2027-12-31 · NCT06251375 · CT.gov ↗
What to watch
Early phase / not applicableBrain TumorNot yet recruiting
Est. primary completion 2027-12-31 · NCT06863064 · CT.gov ↗
What to watch
Early phase / not applicablePostoperative Pain, Analgesia, Supratentorial Brain TumorNot yet recruiting
Est. primary completion 2027-12-31 · NCT07441421 · CT.gov ↗
What to watch
2028 (10)
January 2028 (1)
Early phase / not applicableOrofacial Clefts, Cleft Lip and Palate, Alveolar Ridge DefectRecruiting
Est. primary completion 2028-01 · NCT07340008 · CT.gov ↗
What to watch
February 2028 (1)
Early phase / not applicableSedation, Endoscopy, Colonoscopy, Endoscopic Retrograde Cholangiopancreatography (ERCP)Not yet recruiting
Est. primary completion 2028-02 · NCT07649746 · CT.gov ↗
What to watch
April 2028 (1)
Phase 4Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve StenosisRecruiting
Est. primary completion 2028-04 · NCT07556523 · CT.gov ↗
What to watch
May 2028 (3)
Phase 4Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids, Spinal Anesthesia for Cesarean Section, Dexmedetomidine, Clonidine …Not yet recruiting
Est. primary completion 2028-05 · NCT07567495 · CT.gov ↗
What to watch
Early phase / not applicableAnesthesia and NeurotoxicityActive not recruiting
Est. primary completion 2028-05-30 · NCT04364945 · CT.gov ↗
What to watch
Early phase / not applicableObesity, Pain, PostoperativeRecruiting
Est. primary completion 2028-05-31 · NCT03756961 · CT.gov ↗
What to watch
June 2028 (1)
Early phase / not applicableModerate-to-Severe Traumatic Brain InjuryNot yet recruiting
Est. primary completion 2028-06-01 · NCT07678216 · CT.gov ↗
What to watch
July 2028 (1)
Early phase / not applicableDental AnxietyNot yet recruiting
Est. primary completion 2028-07-23 · NCT05500261 · CT.gov ↗
What to watch
September 2028 (1)
Early phase / not applicableCardiac Disease Minimally Invasive Cardiac Surgery Postoperative PainNot yet recruiting
Est. primary completion 2028-09-01 · NCT07749274 · CT.gov ↗
What to watch
December 2028 (1)
Early phase / not applicablePediatric Procedural SedationNot yet recruiting
Est. primary completion 2028-12-31 · NCT07768566 · CT.gov ↗
What to watch
2029 (4)
January 2029 (1)
Phase 4Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy, Intensive Care Units (ICUs), Agitation, Sedation and AnalgesiaNot yet recruiting
Est. primary completion 2029-01-01 · NCT07377981 · CT.gov ↗
What to watch
April 2029 (1)
Phase 3Delirium in the Intensive Care UnitNot yet recruiting
Est. primary completion 2029-04-15 · NCT07542990 · CT.gov ↗
What to watch
December 2029 (2)
Early phase / not applicableAged, Intensive Care Units, Ventilators, Mechanical, Dexmedetomidine, Esketamine, DeliriumNot yet recruiting
Est. primary completion 2029-12-01 · NCT06468436 · CT.gov ↗
What to watch
Phase 3Non-Invasive VentilationRecruiting
Est. primary completion 2029-12-31 · NCT06259565 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.