picankibart vs SHR-1139

NCT05645627 · Phase 3 · completed

This was a randomized, quadruple-blind, placebo-controlled trial with 500 participants. The sponsor reports that picankibart met its co-primary endpoints, with 80.3% of picankibart patients reaching PASI90 (at least 90% skin clearance) at week 16, compared with 2.0% of placebo patients, a highly significant difference.

Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.

NCT07051538 · Phase 1 · completed

This early-phase study randomized 64 participants to SHR-1139 or placebo under full blinding, but it was designed to check safety and tolerability, not to test whether the drug improves psoriasis, and no results have been posted, so no conclusion about benefit can yet be drawn from it.

NCT05377580 · Phase 2 · completed

This trial randomized 150 patients with moderate-to-severe ulcerative colitis to picankibart at several doses or placebo under double-blind conditions, with clinical remission at Week 12 as the primary measure. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.

Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.

No graded featured trial for this indication yet; the grade above reflects that absence, not a judgment.