Head-to-head evidence
ION904 vs Tonlamarsen
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Hypertension
Shared mechanism: Angiotensinogen (AGT) · full Hypertension pipeline
ION904
Developed by Ionis Pharmaceuticals
NCT05314439 · Phase 2 · completed
The study randomly assigned 48 participants to ION904 or placebo and masked participants, investigators, and outcome assessors. However, its primary endpoint was the surrogate biomarker plasma angiotensinogen, and no primary endpoint results have been posted.
Tonlamarsen
Developed by Kardigan
NCT06864104 · Phase 2 · completed
The study randomized 206 participants to tonlamarsen or placebo with participants, care providers, investigators, and outcome assessors masked. Its primary outcomes were changes in plasma angiotensinogen. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
Next expected readout: December 2026 · NCT07511361 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: ION904's landscape · Tonlamarsen's landscape