Head-to-head evidence
Henagliflozin vs SP2086
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Type 2 Diabetes
Shared mechanism: DPP-4 · full Type 2 Diabetes pipeline
Henagliflozin
Developed by Jiangsu Hengrui Pharmaceuticals
NCT03159052 · Phase 3 · status unknown
This was a randomized, quadruple-blind, placebo-controlled trial (n=450). The primary endpoint, HbA1c change at 24 weeks, was clearly met: both the 5 mg and 10 mg doses reduced HbA1c significantly more than placebo (p<.001 for each).
Next expected readout: December 2026 · NCT06448130 (registry estimate)
SP2086
Developed by Jiangsu Hengrui Pharmaceuticals
NCT01970033 · Phase 3 · status unknown
This is a large, randomized, quadruple-blind, placebo-controlled trial using the standard glycemic control measure for diabetes as its primary endpoint, but no results have been posted yet, so whether the drug lowered HbA1c more than placebo is unknown. (Independently confirmed by a second model, in-session-confirm:claude-opus-20260822.)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Henagliflozin's landscape · SP2086's landscape