Head-to-head evidence
amycretin vs AZD6234
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Obesity
Shared mechanism: Amylin receptor · full Obesity pipeline
amycretin
Developed by Novo Nordisk
NCT06064006 · Phase 2 · completed
The study was randomized, quadruple-masked, and placebo-controlled, with 125 participants, providing a meaningful controlled design. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.
This trial's registered primary endpoint was safety (treatment-emergent adverse events); the figures shown are its prespecified secondary weight-change endpoints as published in The Lancet.
Next expected readout: December 2027 · NCT07587710 (registry estimate)
AZD6234
Developed by AstraZeneca
NCT06595238 · Phase 2 · completed
Randomized, quadruple-blind, placebo-controlled Phase 2 trial in 262 participants with obesity or overweight; primary endpoint Percent change in body weight from baseline to week 26. Completed December 2025; numerical results not yet posted to the registry, so the grade is the design ceiling for a completed controlled study without results.
Next expected readout: October 2026 · NCT07017179 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: amycretin's landscape · AZD6234's landscape