Mechanism
5T4 (trophoblast glycoprotein) / TRBV7-9 T-cell receptor
Assets acting on this target.
- Class
- Tumor-targeted superantigen fusion protein (5T4 antibody fragment fused to engineered superantigen SEA/E-120; naptumomab estafenatox)
- Pathway
- 5T4-antibody moiety anchors the fusion protein to tumor cells; the superantigen moiety selectively engages TRBV7-9-expressing cytotoxic T lymphocytes to trigger tumor cell killing
Research
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