Asset profile
zanubrutinib · Brukinsa
Small molecule
Approved / Phase 4Mechanism not established
Approvedregulatory verdict
Evidence outlook
Approved: Mantle Cell Lymphoma
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
How the evidence outlook works ↗
Featured trials
Research
Unlock featured-trial analysis
Research includes the instrumental studies, endpoints, key results, design grades, rationales and source links behind the Outlook.
Competitive landscape
No competitors sharing a mechanism or indication in the current universe.
Upcoming events
(108 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (18)
October 2026 (2)
Phase 2Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation, EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified …Active not recruiting
Est. primary completion 2026-10-09 · NCT05202782 · CT.gov ↗
What to watch
Phase 2Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)Recruiting
Est. primary completion 2026-10-28 · NCT05168930 · CT.gov ↗
What to watch
November 2026 (4)
Phase 2Chronic Lymphocytic LeukemiaActive not recruiting
Est. primary completion 2026-11 · NCT06637501 · CT.gov ↗
What to watch
Phase 2Diffuse Large B Cell LymphomaNot yet recruiting
Est. primary completion 2026-11 · NCT06669143 · CT.gov ↗
What to watch
Phase 2DLBCLNot yet recruiting
Est. primary completion 2026-11-01 · NCT06652165 · CT.gov ↗
What to watch
Phase 2B-NHL, CART TherapyRecruiting
Est. primary completion 2026-11-20 · NCT06695013 · CT.gov ↗
What to watch
December 2026 (12)
Phase 2Diffuse Large B Cell Lymphoma (DLBCL)Not yet recruiting
Est. primary completion 2026-12 · NCT06594432 · CT.gov ↗
What to watch
Phase 2Follicular LymphomaNot yet recruiting
Est. primary completion 2026-12-01 · NCT06549335 · CT.gov ↗
What to watch
Phase 2Waldenstrom MacroglobulinemiaRecruiting
Est. primary completion 2026-12-01 · NCT06561347 · CT.gov ↗
What to watch
Phase 2Ann Arbor Stage II Follicular Lymphoma, Grade 1 Follicular Lymphoma, Ann Arbor Stage III Follicular Lymphoma …Recruiting
Est. primary completion 2026-12-30 · NCT06471738 · CT.gov ↗
What to watch
Phase 1/2Large B-cell LymphomaRecruiting
Est. primary completion 2026-12-31 · NCT06375733 · CT.gov ↗
What to watch
Phase 2Recurrent Transformed Chronic Lymphocytic Leukemia, Refractory Transformed Chronic Lymphocytic Leukemia …Recruiting
Est. primary completion 2026-12-31 · NCT05873712 · CT.gov ↗
What to watch
Phase 2Grade 3b Follicular Lymphoma, High Grade B-Cell Lymphoma, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements …Recruiting
Est. primary completion 2026-12-31 · NCT05890352 · CT.gov ↗
What to watch
Phase 2Mantle Cell LymphomaActive not recruiting
Est. primary completion 2026-12-31 · NCT06504199 · CT.gov ↗
What to watch
Phase 2Mucosa-associated Lymphoid Tissue Lymphoma (MALT)Active not recruiting
Est. primary completion 2026-12-31 · NCT06647732 · CT.gov ↗
What to watch
Phase 2Monoclonal Gammopathy of Uncertain SignificanceActive not recruiting
Est. primary completion 2026-12-31 · NCT05939037 · CT.gov ↗
What to watch
Phase 3B-cell MalignanciesActive not recruiting
Est. primary completion 2026-12-31 · NCT04170283 · CT.gov ↗
What to watch
2027 (28)
February 2027 (2)
March 2027 (1)
Phase 2Leukemia, Lymphocytic, Chronic, B-CellActive not recruiting
Est. primary completion 2027-03 · NCT05650723 · CT.gov ↗
What to watch
April 2027 (3)
Phase 4Hemophagocytic Lymphohistiocytosis, B Cell LymphomaRecruiting
Est. primary completion 2027-04 · NCT07270835 · CT.gov ↗
What to watch
Phase 2Chronic Lymphocytic LeukemiaNot yet recruiting
Est. primary completion 2027-04-30 · NCT07674810 · CT.gov ↗
What to watch
Early phase / not applicableWaldenström's Macroglobulinemia (WM)Not yet recruiting
Est. primary completion 2027-04-30 · NCT06942507 · CT.gov ↗
What to watch
May 2027 (2)
June 2027 (4)
Phase 1Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRecruiting
Est. primary completion 2027-06 · NCT03666000 · CT.gov ↗
What to watch
Phase 2B-cell Non Hodgkin LymphomaNot yet recruiting
Est. primary completion 2027-06-01 · NCT06646666 · CT.gov ↗
What to watch
Phase 2Chronic Lymphocytic LeukemiaNot yet recruiting
Est. primary completion 2027-06-01 · NCT07003464 · CT.gov ↗
What to watch
Phase 2Follicular Lymphoma ( FL)Recruiting
Est. primary completion 2027-06-30 · NCT06959732 · CT.gov ↗
What to watch
July 2027 (2)
August 2027 (1)
Phase 2Richter TransformationRecruiting
Est. primary completion 2027-08 · NCT04271956 · CT.gov ↗
What to watch
October 2027 (2)
November 2027 (2)
December 2027 (9)
Phase 2Follicular Lymphoma, LymphomaRecruiting
Est. primary completion 2027-12 · NCT05389293 · CT.gov ↗
What to watch
Phase 2Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)Recruiting
Est. primary completion 2027-12-01 · NCT06958705 · CT.gov ↗
What to watch
Phase 1Recurrent Transformed Chronic Lymphocytic Leukemia, Refractory Transformed Chronic Lymphocytic Leukemia, Richter Syndrome …Recruiting
Est. primary completion 2027-12-13 · NCT06735664 · CT.gov ↗
What to watch
Phase 2Central Nervous System LymphomaNot yet recruiting
Est. primary completion 2027-12-30 · NCT07405255 · CT.gov ↗
What to watch
Phase 2Lymphoma, Mantle-Cell, Lymphoma, Non-HodgkinNot yet recruiting
Est. primary completion 2027-12-30 · NCT06427213 · CT.gov ↗
What to watch
Phase 2Relapsed/Refractory Follicular LymphomaRecruiting
Est. primary completion 2027-12-31 · NCT07418190 · CT.gov ↗
What to watch
Phase 2Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRecruiting
Est. primary completion 2027-12-31 · NCT07734038 · CT.gov ↗
What to watch
Phase 2CLL (Chronic Lymphocytic Leukemia)Recruiting
Est. primary completion 2027-12-31 · NCT07671378 · CT.gov ↗
What to watch
2028 (31)
January 2028 (1)
Phase 2Primary Central Nervous System Lymphoma (PCNSL), Non Hodgkin Lymphoma (NHL)Not yet recruiting
Est. primary completion 2028-01-01 · NCT06646211 · CT.gov ↗
What to watch
February 2028 (2)
Phase 2Primary Central Nervous System Lymphoma, Secondary Central Nervous System Lymphoma, Relapsed Cancer, Refractory CancerRecruiting
Est. primary completion 2028-02 · NCT05681195 · CT.gov ↗
What to watch
Phase 2Diffuse Large B Cell Lymphoma (DLBCL)Recruiting
Est. primary completion 2028-02-29 · NCT07371923 · CT.gov ↗
What to watch
March 2028 (2)
April 2028 (2)
May 2028 (3)
Phase 2Lymphoma, Mantle-CellRecruiting
Est. primary completion 2028-05 · NCT06558604 · CT.gov ↗
What to watch
Phase 1/2Mantle Cell LymphomaRecruiting
Est. primary completion 2028-05-01 · NCT06029309 · CT.gov ↗
What to watch
Phase 2BTK Inhibitors, Follicular Lymphoma, ImmunochemotherapyNot yet recruiting
Est. primary completion 2028-05-01 · NCT06918015 · CT.gov ↗
What to watch
June 2028 (1)
Phase 2Waldenström Macroglobulinemia (WM)Not yet recruiting
Est. primary completion 2028-06-30 · NCT07259122 · CT.gov ↗
What to watch
July 2028 (2)
Phase 3Relapsed/Refractory Follicular Lymphoma, Marginal Zone LymphomaActive not recruiting
Est. primary completion 2028-07 · NCT05100862 · CT.gov ↗
What to watch
Early phase / not applicableFollicular Lymphoma, Treatment NaiveRecruiting
Est. primary completion 2028-07-15 · NCT07126678 · CT.gov ↗
What to watch
August 2028 (4)
Phase 2Mantle Cell LymphomaRecruiting
Est. primary completion 2028-08-01 · NCT06839053 · CT.gov ↗
What to watch
Phase 3Diffuse Large B-Cell LymphomaRecruiting
Est. primary completion 2028-08-10 · NCT06522555 · CT.gov ↗
What to watch
Phase 2Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaNot yet recruiting
Est. primary completion 2028-08-13 · NCT07812246 · CT.gov ↗
What to watch
Phase 3Mantle Cell LymphomaRecruiting
Est. primary completion 2028-08-31 · NCT06742996 · CT.gov ↗
What to watch
September 2028 (3)
Phase 2Mantle Cell LymphomaNot yet recruiting
Est. primary completion 2028-09 · NCT07799220 · CT.gov ↗
What to watch
Phase 2Follicular LymphomaActive not recruiting
Est. primary completion 2028-09-15 · NCT06492837 · CT.gov ↗
What to watch
Phase 3Chronic Lymphocytic Leukemia, Small Lymphocytic LeukemiaRecruiting
Est. primary completion 2028-09-30 · NCT07321652 · CT.gov ↗
What to watch
October 2028 (2)
December 2028 (9)
Phase 1/2B-cell Malignancy, Relapsed Cancer, Refractory Cancer, B-cell LymphomaRecruiting
Est. primary completion 2028-12-02 · NCT06634589 · CT.gov ↗
What to watch
Phase 1Immune ThrombocytopeniaNot yet recruiting
Est. primary completion 2028-12-30 · NCT07315373 · CT.gov ↗
What to watch
Phase 1/2Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, LymphomaRecruiting
Est. primary completion 2028-12-31 · NCT07052695 · CT.gov ↗
What to watch
Phase 2Waldenstrom MacroglobulinemiaNot yet recruiting
Est. primary completion 2028-12-31 · NCT06547866 · CT.gov ↗
What to watch
Phase 2Large B-Cell Lymphoma (LBCL)Recruiting
Est. primary completion 2028-12-31 · NCT07514169 · CT.gov ↗
What to watch
Phase 2Hairy Cell Leukemia, Hairy Cell Leukemia VariantEnrolling by invitation
Est. primary completion 2028-12-31 · NCT07690761 · CT.gov ↗
What to watch
Phase 2Splenic B-cell Lymphoma/Leukaemia With Prominent Nucleoli，SBLPNRecruiting
Est. primary completion 2028-12-31 · NCT07165769 · CT.gov ↗
What to watch
Phase 2Diffuse Large B-Cell Lymphoma (DLBCL)Recruiting
Est. primary completion 2028-12-31 · NCT07608978 · CT.gov ↗
What to watch
2029 (16)
January 2029 (2)
March 2029 (2)
April 2029 (2)
May 2029 (2)
June 2029 (1)
Phase 2Large B-Cell Lymphoma (LBCL)Not yet recruiting
Est. primary completion 2029-06-30 · NCT07717177 · CT.gov ↗
What to watch
July 2029 (1)
Phase 2Diffuse Large B-cell Lymphoma, DLBCL - Diffuse Large B Cell LymphomaRecruiting
Est. primary completion 2029-07-31 · NCT06846463 · CT.gov ↗
What to watch
November 2029 (2)
December 2029 (4)
Phase 2Diffuse Large B-cell LymphomaRecruiting
Est. primary completion 2029-12 · NCT06664411 · CT.gov ↗
What to watch
Phase 2Mantle Cell LymphomaRecruiting
Est. primary completion 2029-12-31 · NCT07341191 · CT.gov ↗
What to watch
Phase 2CLL / SLLNot yet recruiting
Est. primary completion 2029-12-31 · NCT07682415 · CT.gov ↗
What to watch
Phase 2BTK Inhibitors, Histone Deacetylase Inhibitor, Double Express Diffuse Large B-cell LymphomaNot yet recruiting
Est. primary completion 2029-12-31 · NCT06890585 · CT.gov ↗
What to watch
2030 (6)
February 2030 (1)
Phase 2Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaNot yet recruiting
Est. primary completion 2030-02-28 · NCT06367374 · CT.gov ↗
What to watch
March 2030 (2)
Phase 2Follicular Lymphoma, Lymphoma, Non-Hodgkin Lymphoma, Relapsed Lymphoma, Refractory Lymphoma, Marginal Zone LymphomaRecruiting
Est. primary completion 2030-03-01 · NCT06563596 · CT.gov ↗
What to watch
Phase 2Follicular LymphomasNot yet recruiting
Est. primary completion 2030-03-23 · NCT07505849 · CT.gov ↗
What to watch
April 2030 (1)
Phase 1CNS LymphomaRecruiting
Est. primary completion 2030-04-30 · NCT06730542 · CT.gov ↗
What to watch
June 2030 (1)
Phase 2Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRecruiting
Est. primary completion 2030-06-30 · NCT06520098 · CT.gov ↗
What to watch
July 2030 (1)
Phase 2Diffuse Large B-cell LymphomaRecruiting
Est. primary completion 2030-07-30 · NCT06503263 · CT.gov ↗
What to watch
2031 (3)
February 2031 (1)
Phase 3Chronic Lymphocytic LeukemiaRecruiting
Est. primary completion 2031-02 · NCT07277231 · CT.gov ↗
What to watch
March 2031 (1)
Phase 2Anti-MAG IgM-associated Demyelinating PolyneuropathyRecruiting
Est. primary completion 2031-03 · NCT07392229 · CT.gov ↗
What to watch
April 2031 (1)
Early phase / not applicableMarginal Zone Lymphoma(MZL)Not yet recruiting
Est. primary completion 2031-04-30 · NCT07299331 · CT.gov ↗
What to watch
2032 (3)
January 2032 (1)
Phase 1Relapsed or Refractory B-cell Non-Hodgkin LymphomaActive not recruiting
Est. primary completion 2032-01 · NCT06824701 · CT.gov ↗
What to watch
February 2032 (1)
Phase 3CLLActive not recruiting
Est. primary completion 2032-02 · NCT06073821 · CT.gov ↗
What to watch
May 2032 (1)
Phase 2Chronic Lymphocytic Leukemia, Small Lymphocytic LymphomaRecruiting
Est. primary completion 2032-05-31 · NCT06544785 · CT.gov ↗
What to watch
2034 (1)
April 2034 (1)
Phase 2Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue, Recurrent Nodal Marginal Zone Lymphoma …Not yet recruiting
Est. primary completion 2034-04-03 · NCT07638722 · CT.gov ↗
What to watch
2036 (1)
December 2036 (1)
Phase 4Waldenstrom Macroglobulinaemia, Multiple MyelomaNot yet recruiting
Est. primary completion 2036-12 · NCT07474961 · CT.gov ↗
What to watch
2038 (1)
August 2038 (1)
Phase 3Mantle Cell LymphomaRecruiting
Est. primary completion 2038-08-31 · NCT05976763 · CT.gov ↗
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.