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NBTXR3

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Earlyevidence

Evidence outlook

Mid-stage studies underway, no completed readout

Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

Also in development:Non-Small Cell Lung Cancer · Phase 1/2

How the evidence outlook works ↗

Competitive landscape

65 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 65 same-indication; 58 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
NBTXR3: this drugPhase 3NanoparticleHafnium-oxide nanoparticle radioenhancer
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A
BinimetinibApprovedSmall moleculeMEK1/2
BrigatinibApprovedSmall moleculeALK
CapmatinibApprovedSmall moleculeMET
CemiplimabApprovedMonoclonal antibodyPD-1
CeritinibApprovedSmall moleculeALK
CrizotinibApprovedSmall moleculeALK, ROS1, MET/HGFR, and RON

…and 50 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(8 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 1Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma …Active not recruiting
Est. primary completion 2026-12-31 · NCT04484909 · CT.gov ↗
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2027 (2)
April 2027 (1)
Phase 1Non-Small Cell Lung CancerActive not recruiting
Est. primary completion 2027-04-30 · NCT03589339 · CT.gov ↗
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October 2027 (1)
Phase 1Cervical Esophagus Adenocarcinoma, Clinical Stage II Esophageal Adenocarcinoma AJCC v8 …Recruiting
Est. primary completion 2027-10-31 · NCT04615013 · CT.gov ↗
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2028 (5)
February 2028 (1)
Phase 1/2Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver, Metastatic Malignant Neoplasm in the Lung …Recruiting
Est. primary completion 2028-02-01 · NCT05039632 · CT.gov ↗
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March 2028 (1)
Phase 1Recurrent Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8 …Active not recruiting
Est. primary completion 2028-03-31 · NCT04505267 · CT.gov ↗
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June 2028 (1)
Phase 3Carcinoma, Squamous CellRecruiting
Est. primary completion 2028-06-30 · NCT04892173 · CT.gov ↗
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July 2028 (1)
Phase 1Squamous Cell Carcinoma of Head and NeckRecruiting
Est. primary completion 2028-07-14 · NCT07219212 · CT.gov ↗
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August 2028 (1)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-08-30 · NCT07224152 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (1)
Phase 2/3 (1)
Phase 2 (2)
Phase 1/2 (6)
Phase 1 (6)
Early phase / not applicable (1)