Asset profile
Lotivibart
Monoclonal antibody
Evidence outlook · lead readout
NCT04871113 · HIV Infections
The reported results come from study designs that frequently fail to replicate under controlled conditions — see the rationale below.
NCT04871113: Participants were randomized among dose cohorts, but the study was open-label, had no placebo or active comparator during monotherapy, and included only 6 to 16 participants per cohort. The primary endpoint was the surrogate measure of maximum decline in HIV-1 RNA and was reported descriptively without a formal comparative efficacy test, so the findings do not establish comparative treatment benefit.
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