Asset profile

Ifinatamab Deruxtecan

Antibody–drug conjugate

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Earlyevidence

Evidence outlook

Mid-stage studies underway, no completed readout

Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

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Competitive landscape

66 competitors in this universe: 6 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 58 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Ifinatamab Deruxtecan: this drugPhase 3Antibody–drug conjugateB7-H3
7MW3711Phase 3Antibody–drug conjugateB7-H3
BNT324Phase 3Antibody–drug conjugateB7-H3
GSK5764227Phase 3Small moleculeB7-H3
YL201Phase 3Small moleculeB7-H3
177Lu-BetaBartPhase 1/2RadiopharmaceuticalB7-H3
ITC-6146ROPhase 1Antibody–drug conjugateB7-H3
Afatinib (Gilotrif)ApprovedSmall moleculeEGFR/HER1, HER2, HER4
Alectinib (Alecensa)ApprovedSmall moleculeALK
Alymsys (bevacizumab-Maly)ApprovedMonoclonal antibodyVEGF-A
AmivantamabApprovedMultispecific antibodyEGFR x c-MET
AtezolizumabApprovedMonoclonal antibodyPD-L1
BAT1706 (Avzivi)ApprovedMonoclonal antibodyVEGF-A
BAY2927088 (Hyrnuo)ApprovedSmall moleculeHER2 (ERBB2) exon 20 insertions and point mutations; also mutant-selective EGFR
BevacizumabApprovedMonoclonal antibodyVEGF-A, Vascular Endothelial Growth Factor Inhibitor
Bevacizumab-Awwb (MVASI)ApprovedMonoclonal antibodyVEGF-A

…and 51 more. Research shows the complete landscape.

Research

Unlock the full comparison

Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(16 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (3)
April 2027 (1)
Phase 1/2Advanced Solid Tumor, Malignant Solid TumorRecruiting
Est. primary completion 2027-04-30 · NCT04145622 · CT.gov ↗
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June 2027 (1)
Phase 1/2Oesophageal Squamous Cell CarcinomaRecruiting
Est. primary completion 2027-06-12 · NCT07405151 · CT.gov ↗
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July 2027 (1)
Phase 1/2Extensive Stage-small Cell Lung CancerRecruiting
Est. primary completion 2027-07-20 · NCT06362252 · CT.gov ↗
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2028 (5)
January 2028 (2)
Phase 1/2Small-Cell Lung Cancer, Neuroendocrine CarcinomaActive not recruiting
Est. primary completion 2028-01-28 · NCT04471727 · CT.gov ↗
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Phase 3Small Cell Lung CancerRecruiting
Est. primary completion 2028-01-30 · NCT06203210 · CT.gov ↗
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June 2028 (2)
Phase 3Esophageal Squamous Cell CarcinomaRecruiting
Est. primary completion 2028-06-01 · NCT06644781 · CT.gov ↗
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Phase 3Prostate Cancer, Prostatic NeoplasmsRecruiting
Est. primary completion 2028-06-26 · NCT06925737 · CT.gov ↗
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July 2028 (1)
Phase 1/2Recurrent or Metastatic Solid TumorsRecruiting
Est. primary completion 2028-07-25 · NCT06330064 · CT.gov ↗
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2029 (1)
April 2029 (1)
Phase 1/2Small Cell Lung CancerRecruiting
Est. primary completion 2029-04-27 · NCT06780137 · CT.gov ↗
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2030 (1)
November 2030 (1)
Phase 1/2Small Cell Lung Cancer Extensive StageRecruiting
Est. primary completion 2030-11-29 · NCT07227597 · CT.gov ↗
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2031 (2)
April 2031 (1)
Phase 1/2Castration-Resistant Prostatic Cancer, MetastasisRecruiting
Est. primary completion 2031-04-01 · NCT06863272 · CT.gov ↗
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August 2031 (1)
Phase 1/2Malignant NeoplasmRecruiting
Est. primary completion 2031-08-17 · NCT07630974 · CT.gov ↗
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2032 (4)
January 2032 (1)
Phase 1/2Esophageal Squamous Cell CarcinomaRecruiting
Est. primary completion 2032-01-04 · NCT06780111 · CT.gov ↗
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February 2032 (1)
Phase 1/2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2032-02-13 · NCT04165070 · CT.gov ↗
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March 2032 (2)
Phase 2Lung NeoplasmRecruiting
Est. primary completion 2032-03-02 · NCT06780098 · CT.gov ↗
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Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2032-03-12 · NCT06780085 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (3)
Phase 2 (3)
Phase 1/2 (11)