Asset profile

EVO756

Small molecule

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Earlyevidence

Evidence outlook

Mid-stage studies underway, no completed readout

Phase 2 studies are registered but none has completed a readout, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

Also in development:Chronic Inducible Urticaria · Phase 2

How the evidence outlook works ↗

Competitive landscape

52 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 52 same-indication; 49 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
EVO756: this drugPhase 2Small moleculeMRGPRX2
Almotriptan (Axert)ApprovedSmall molecule—
Aspirin / Acetaminophen / Caffeine (Excedrin Migraine)Approved——
Atogepant (Qulipta)ApprovedSmall molecule—
Celecoxib (Elyxyb)ApprovedSmall molecule—
Diclofenac Potassium (Cambia)ApprovedSmall moleculeNonsteroidal Anti-inflammatory Drug
Dihydroergotamine (Atzumi)Approved——
Dihydroergotamine Mesylate (Brekiya)Approved——
Dihydroergotamine Mesylate (D.H.E. 45)Approved——
Dihydroergotamine Mesylate (Migranal)Approved——
Divalproex Sodium (Depakote ER)Approved—GABAergic neurotransmission
Divalproex Sodium (Depakote)ApprovedSmall moleculeGABAergic neurotransmission
Eletriptan (Relpax)ApprovedSmall molecule—
Eptinezumab (Vyepti)ApprovedMonoclonal antibody—
Erenumab (Aimovig)ApprovedMonoclonal antibody—
Ergotamine / Caffeine (Cafergot)Approved——

…and 37 more. Research shows the complete landscape.

Research

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(1 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (1)
October 2027 (1)
Phase 2MigraineRecruiting
Est. primary completion 2027-10 · NCT07616128 · CT.gov ↗
What to watch
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 2 (4)