Asset profile

Ceralasertib

Small molecule

Phase 3underway

Evidence outlook · registrational

Non-Small Cell Lung Cancer: registrational readout pending

Entered Phase 3 on weak signal mid-stage evidence. Registrational readout expected around 2028-06-30.

NCT02664935: Patients in this arm were not randomized against a comparison group; they were assigned to the ceralasertib-plus-durvalumab arm based on their tumor's molecular profile and treated openly, with outcomes tracked only within that single group. No results have been posted for this arm yet, so no conclusion about effect can currently be drawn.

How the evidence outlook works ↗

Upcoming events

(5 total)

Estimated primary-completion dates from ClinicalTrials.gov — registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 2Breast Neoplasm, Triple Negative Breast Cancer (TNBC), HRDRecruiting
Est. primary completion 2026-12 · NCT03740893 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2027 (2)
December 2027 (2)
Phase 2Triple Negative Breast Cancer MetastaticRecruiting
Est. primary completion 2027-12 · NCT05582538 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 2Advanced Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 …Recruiting
Est. primary completion 2027-12-31 · NCT04090567 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

2028 (2)
June 2028 (2)
Phase 2Non-Small Cell Lung CancerRecruiting
Est. primary completion 2028-06 · NCT06680050 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

Phase 3Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8Active not recruiting
Est. primary completion 2028-06-30 · NCT06732401 · CT.gov ↗
What to watch

Research analysis

Source-grounded endpoint goals, benchmarks, comparator context, and caveats for this readout are included with Research.

See the full readout calendar ↗

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