Asset profile

Aficamten

Small molecule

Approved / Phase 4Mechanism not established
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Approvedregulatory verdict

Evidence outlook

Approved: Hypertrophic Cardiomyopathy

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

track record: Reliable signal

How the evidence outlook works ↗

Competitive landscape

1 competitor in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 1 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Aficamten: this drugApprovedSmall molecule—
Sotagliflozin (Inpefa)ApprovedSmall moleculeSGLT1/2 (dual)
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(3 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
December 2026 (1)
Phase 4Hypertrophic CardiomyopathyRecruiting
Est. primary completion 2026-12-31 · NCT07600177 · CT.gov ↗
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2028 (1)
March 2028 (1)
Phase 2/3Hypertrophic CardiomyopathyEnrolling by invitation
Est. primary completion 2028-03 · NCT04848506 · CT.gov ↗
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2030 (1)
January 2030 (1)
Phase 2/3Hypertrophic CardiomyopathyActive not recruiting
Est. primary completion 2030-01 · NCT06412666 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (5)
Phase 2/3 (2)
Phase 2 (1)
Phase 1 (3)
Phase 4 (1)