Head-to-head evidence

orforglipron vs regor GLP-1

Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.

Obesity

Shared mechanism: GLP-1 receptor · full Obesity pipeline

orforglipron · Foundayo

Marketed by Eli Lilly

Approved in Obesitysmall molecule
Partial signal

NCT05803421 · Phase 3 · completed

The study is randomized and active-controlled with a large sample of 2,749 participants, but it is open-label rather than blinded. Its primary endpoint is a hard clinical cardiovascular outcome; however, the comparison cannot be judged because no results are currently available.

Next expected readout: February 2027 · NCT06672549 (registry estimate)

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regor GLP-1

Developed by Regor Pharmaceuticals

Phase 2 in Obesitysmall molecule
Partial signal

NCT06867718 · Phase 2 · completed

The trial randomized 267 participants to four active-dose groups or placebo and masked both participants and investigators. Its primary endpoint was percent change in body weight at Week 36, but the registry does not report whether the comparison met its statistical objective, so the evidence is currently limited to a well-controlled study design with an unknown result.

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Type 2 Diabetes

Shared mechanism: GLP-1 receptor · full Type 2 Diabetes pipeline

orforglipron · Foundayo

Marketed by Eli Lilly

Phase 3 in Type 2 Diabetessmall molecule
Partial signal

NCT05803421 · Phase 3 · completed

The study is randomized and active-controlled with a large sample of 2,749 participants, but it is open-label rather than blinded. Its primary endpoint is a hard clinical cardiovascular outcome; however, the comparison cannot be judged because no results are currently available.

Next expected readout: May 2027 · NCT07613307 (registry estimate)

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regor GLP-1

Developed by Regor Pharmaceuticals

Phase 2 in Type 2 Diabetessmall molecule
not yet graded

No graded featured trial for this indication yet; the grade above reflects that absence, not a judgment.

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The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: orforglipron's landscape · regor GLP-1's landscape