Head-to-head evidence
Isatuximab vs Mezagitamab
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Multiple Myeloma
Shared mechanism: CD38 · full Multiple Myeloma pipeline
Isatuximab
Marketed by Sanofi
NCT02990338 · Phase 3 · completed
Participants were randomized 1:1 to isatuximab plus pomalidomide and dexamethasone or pomalidomide and dexamethasone alone, but the study was open-label rather than double-blind. The primary clinical endpoint, progression-free survival, was met: median survival was 11.53 versus 6.47 months, with a hazard ratio of 0.596 and p=0.0005.
Next expected readout: November 2026 · NCT06517017 (registry estimate)
Mezagitamab
Developed by Takeda Pharmaceutical Company
NCT03439280 · Phase 1/2 · completed
This was a nonrandomized, open-label, single-arm dose-escalation study of 50 participants, with no placebo or active comparator. Its primary outcomes focused on safety, including treatment-emergent adverse events and dose-limiting toxicities, rather than a controlled efficacy comparison; 50 of 50 participants reported at least one treatment-emergent adverse event, and 1 of 41 dose-limiting-toxicity-evaluable participants had a dose-limiting toxicity.
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Isatuximab's landscape · Mezagitamab's landscape