Head-to-head evidence
Donanemab vs SHR-1707
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Alzheimer's Disease
Shared mechanism: Amyloid-beta (monoclonal antibody) · full Alzheimer's Disease pipeline
Donanemab · Kisunla
Marketed by Eli Lilly
NCT05108922 · Phase 3 · completed
Participants were randomized to donanemab or active-control aducanumab, but the trial was open-label rather than blinded. Both prespecified primary amyloid-clearance comparisons favored donanemab with statistically significant results; the biomarker-based primary endpoint and lack of blinding support a moderate evidence grade rather than a strong one.
Next expected readout: November 2027 · NCT05026866 (registry estimate)
SHR-1707
Developed by Jiangsu Hengrui Pharmaceuticals
NCT05681819 · Phase 1 · completed
The trial randomized 33 participants to SHR-1707 or placebo with triple-blinding, a design able to isolate a genuine drug effect, but its primary outcomes were safety measures rather than a cognitive or functional efficacy endpoint, and results have not yet been posted, so no effect on Alzheimer's disease could be established from this record.
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Donanemab's landscape · SHR-1707's landscape