Head-to-head evidence
albuterol HFA (Armstrong's) vs GW642444M
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Asthma
Shared mechanism: Beta-2 adrenergic receptor · full Asthma pipeline
albuterol HFA (Armstrong's)
Marketed by Amphastar Pharmaceuticals, Inc.
NCT00635505 · Phase 3 · terminated
This is a randomized, quadruple-blind, placebo- and active-controlled study with an adequate sample size measuring lung function directly, but no results have been posted yet, so the outcome is unknown.
GW642444M
Developed by GlaxoSmithKline
NCT00600171 · Phase 2 · completed
The study was randomized and double-blind, compared five GW642444M doses with placebo, and included 614 randomized participants. Its primary lung-function endpoint was a surrogate measure rather than a direct clinical outcome, and the results were mixed across doses: the 12.5, 25, and 50 microgram doses outperformed placebo, while the 3 and 6.25 microgram doses did not.
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: albuterol HFA (Armstrong's)'s landscape · GW642444M's landscape