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Company profile

Otsuka Holdings

Diversified pharma; vasopressin-antagonist franchise (tolvaptan)

4578 · TSE · Japan

Public Market Listing

4578TSE

TSE primary exchange listing

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Assets

(12 total)
12Total Assets
8Approved
2Phase 3 / Filed
2Phase 1–2 / Early
9Diseases
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Showing 12 of 12 assets
Target & Modality
Approved
Dopamine D2 and serotonin 5-HT1A receptors (partial agonist) · Dopamine D2/D3 and serotonin 5-HT1A receptor · Dopamine D2 receptor (partial agonist)Small molecule
Schizophrenia
Approved
Dopamine D2 and serotonin 5-HT1A receptors (partial agonist); serotonin 5-HT2A receptor (antagonist)Combination
Schizophrenia
Approved
Dopamine D2/D3 and serotonin 5-HT1A receptorSmall molecule
Schizophrenia
Approved
Decitabine/cedazuridine fixed combination (DNMT + CDA inhibition)Small molecule
Acute Myeloid Leukemia
Approved
Dopamine D2/D3 and serotonin 5-HT1A receptorSmall molecule
Alzheimer's DiseaseMajor Depressive DisorderSchizophrenia
difamilast(Moizerto / Adquey)
Approved
PDE4Small molecule
Atopic Dermatitis
Opicapone(Ongentys)
Approved
COMT · PDE4Small molecule
Parkinson's Disease
Tolvaptan(Samsca / Jinarc)
Approved
Vasopressin V2 receptorSmall molecule
Heart FailureChronic Kidney Disease
OPC-61815No recent activity
Phase 3
Vasopressin V2 receptorSmall molecule
Heart Failure
Phase 3
TAAR1 (trace amine-associated receptor 1)Small molecule
Schizophrenia
Phase 1/2
Integrin β7 (active-conformer epitope recognized by the MMG49 antibody)Cell therapy
Multiple Myeloma
Phase 1
Undisclosed / early pipelineSmall molecule
Major Depressive DisorderSchizophrenia

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