Mechanism
Vascular extracellular matrix (collagen/elastin) - not a classical
Assets acting on this target.
- Class
- Combination product: light-activated (450nm) small-molecule photosensitizer (naphthimide-class collagen/elastin cross-linker) delivered by balloon catheter, not a systemic pharmacologic agent
- Pathway
- Photochemical cross-linking of native collagen and elastin in the vessel wall to create a reinforced 'natural vascular scaffold', increasing ECM resistance to degradation and abnormal remodeling after angioplasty (peripheral artery disease)
- Notes
- original target text: Vascular extracellular matrix (collagen/elastin) - not a classical drug-receptor target
Research
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