Mechanism
Thymidylate synthase (via 5-FU, released from tegafur)
Assets acting on this target.
- Class
- Oral fluoropyrimidine combination — tegafur (5-FU prodrug) + gimeracil (DPD inhibitor) + oteracil (OPRT inhibitor, gut-toxicity mitigant)
- Pathway
- Antimetabolite inhibition of DNA/RNA synthesis
- Notes
- original target text: Thymidylate synthase (via 5-FU, released from tegafur) and dihydropyrimidine dehydrogenase (inhibited by gimeracil) | original target text: Thymidylate synthase (via 5-FU, released from tegafur) and
Research
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