Mechanism
mTOR (mammalian target of rapamycin) via FKBP12
Assets acting on this target.
- Class
- mTOR inhibitor delivered via drug-coated balloon angioplasty catheter (sirolimus/Rapamune)
- Pathway
- Binds FKBP12 to form a complex that inhibits mTORC1, arresting the cell cycle and suppressing vascular smooth muscle cell proliferation to prevent restenosis after angioplasty
Research
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