Mechanism
ICAM-1 (CD54) and DAF (CD55) - viral entry receptors overexpressed on
Assets acting on this target.
- Class
- Oncolytic virus (Coxsackievirus A21)
- Pathway
- Selectively infects and lyses cancer cells via ICAM-1/DAF receptor overexpression, releasing tumor antigens and driving type I IFN-mediated NK cell and plasmacytoid dendritic cell anti-tumor immune activation
- Notes
- original target text: ICAM-1 (CD54) and DAF (CD55) - viral entry receptors overexpressed on tumor cells
Research
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