Mechanism
FUS1/TUSC2 (tumor suppressor gene product)
Assets acting on this target.
- Class
- Liposomal (DOTAP:cholesterol) nanoparticle gene therapy delivering the TUSC2/FUS1 tumor suppressor gene
- Pathway
- Restores TUSC2/FUS1 tumor suppressor expression in tumor cells, activating the intrinsic apoptotic pathway via MDM2 downregulation, p53 accumulation, and Apaf-1-dependent apoptosis
Research
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