Mechanism
cMET x TROP2 (tumor antigens) x CD3 x CD28 (T-cell signals)
Assets acting on this target.
- Class
- Tetraspecific T-cell engager-expander antibody
- Pathway
- simultaneously engages two tumor antigens (cMET, TROP2) and two T-cell activation signals (CD3, CD28) to drive T-cell cytotoxicity while reducing risk of antigen-escape resistance
Research
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