Asset profile

Tividenofusp alfa

Protein / enzyme therapeutic

Phase 2/3Mechanism not established
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Phase 3underway

Evidence outlook · registrational

Mucopolysaccharidosis Type II: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2027-12.

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Competitive landscape

1 competitor in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 1 same-indication; 1 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Tividenofusp Alfa: this drugPhase 2/3Protein / enzyme therapeutic—
RGX-121Phase 3Gene therapy / editing—
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(3 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (2)
June 2027 (1)
Phase 2/3Mucopolysaccharidosis IIEnrolling by invitation
Est. primary completion 2027-06 · NCT06075537 · CT.gov ↗
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December 2027 (1)
Phase 2/3Mucopolysaccharidosis IIActive not recruiting
Est. primary completion 2027-12 · NCT05371613 · CT.gov ↗
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2031 (1)
February 2031 (1)
Phase 1/2Mucopolysaccharidosis IIActive not recruiting
Est. primary completion 2031-02 · NCT04251026 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 2/3 (2)
Phase 1/2 (1)