Asset profile

RP2

Other

Phase 2/3Mechanism not established
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Earlyevidence

Evidence outlook

Early-stage evidence only

Phase 1 / first-in-human studies establish safety, tolerability, and dosing; they are not designed to demonstrate efficacy, so no evidence signal is assigned yet. The first graded signal arrives with a completed confirmatory readout.

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Competitive landscape

13 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 13 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
RP2: this drugPhase 2/3Oncolytic Virus—
ALG.APV-527Phase 1/2Multispecific antibody—
BT5528Phase 1/2PeptideEphA2
CR-001Phase 1/2Multispecific antibody—
LP-184Phase 1/2Small moleculePTGR1 (Prostaglandin Reductase 1, bioactivating enzyme)
PYX-201Phase 1/2Small molecule—
RezatapoptPhase 1/2Small moleculep53 reactivator
XTX501Phase 1/2Multispecific antibodyPD-1/PD-L1 axis; IL-2 receptor βγ (IL-2Rβγ)
BBO-10203Phase 1Small moleculeRAS:PI3Kα protein-protein interaction
COM902Phase 1Monoclonal antibodyTIGIT
JANX008Phase 1Small moleculeEGFR
NXP900Phase 1Small moleculeSRC and YES1 (Src-family kinases)
RP3Phase 1Oncolytic Virus—
LinebackerNot yet studiedSmall molecule—
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(5 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2026 (1)
October 2026 (1)
Phase 1CancerActive not recruiting
Est. primary completion 2026-10-31 · NCT04336241 · CT.gov ↗
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2027 (3)
January 2027 (1)
Phase 2High-Risk Oral Precancerous DiseaseRecruiting
Est. primary completion 2027-01-01 · NCT06623110 · CT.gov ↗
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November 2027 (1)
Phase 2Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Gastroesophageal Junction AdenocarcinomaNot yet recruiting
Est. primary completion 2027-11-01 · NCT07059611 · CT.gov ↗
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December 2027 (1)
Phase 2Hepatocellular Carcinoma, Biliary Tract CancerRecruiting
Est. primary completion 2027-12-01 · NCT05733598 · CT.gov ↗
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2030 (1)
January 2030 (1)
Phase 2/3Metastatic Uveal MelanomaRecruiting
Est. primary completion 2030-01 · NCT06581406 · CT.gov ↗
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All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 2/3 (1)
Phase 2 (5)
Phase 1 (1)
Early phase / not applicable (1)