Asset profile

peginterferon alfa-2a (Pegasys)

Unknown / undisclosed

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Approvedregulatory verdict

Evidence outlook

Approved: Chronic Hepatitis B

Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.

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Competitive landscape

46 competitors in this universe: 2 direct rivals (same mechanism and indication), 5 same-class, 39 same-indication.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Peginterferon Alfa-2a (Pegasys): this drugApproved—Type I interferon receptor
Interferon Alfa-2b (Intron A)Approved—Type I interferon receptor
Human Serum Albumin / Interferon Alpha2b Fusion ProteinPhase 1/2Biologic (subtype unspecified)Type I interferon receptor
AnifrolumabApprovedMonoclonal antibodyType I interferon receptor, Type I interferon receptor subunit 1 (IFNAR1)
Interferon Beta-1bApprovedBiologic (subtype unspecified)Interferon beta receptor (type I IFN signaling), Type I interferon receptor
Interferon-Beta1ApprovedBiologic (subtype unspecified)Type I interferon receptor
Peginterferon Beta-1a (Plegridy)ApprovedBiologic (subtype unspecified)Type I interferon receptor, Interferon beta receptor (type I IFN signaling)
Rebif (interferon Beta 1a)ApprovedBiologic (subtype unspecified)Interferon beta receptor (type I IFN signaling), Type I interferon receptor
Adefovir Dipivoxil (Hepsera)ApprovedSmall molecule—
Entecavir (Baraclude)ApprovedSmall molecule—
Hepatitis B Immune Globulin (HepaGam B)ApprovedSmall molecule—
Lamivudine (Epivir-HBV)Approved——
Telbivudine (Tyzeka)Approved——
Tenofovir Alafenamide (Vemlidy)ApprovedSmall molecule—
Tenofovir Disoproxil Fumarate (Viread)ApprovedSmall moleculeHIV reverse transcriptase (RT)
Diluted I.V.-Hepabig inj(GC5103)Phase 3Biologic (subtype unspecified)—

…and 31 more. Research shows the complete landscape.

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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(2 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (1)
April 2027 (1)
Phase 1Chronic Hepatitis BRecruiting
Est. primary completion 2027-04-30 · NCT07389044 · CT.gov ↗
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2028 (1)
February 2028 (1)
Phase 2Chronic Hepatitis BRecruiting
Est. primary completion 2028-02-29 · NCT06092333 · CT.gov ↗
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See the full readout calendar ↗

All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (38)
Phase 2/3 (4)
Phase 2 (39)
Phase 1/2 (4)
Phase 1 (9)
Phase 4 (60)
Early phase / not applicable (8)
Used as active comparator (12)
Appears in other studies (4)