Asset profile
HiCM-188 (allogeneic iPSC-cardiomyocytes)
Cell therapy
Evidence outlook · registrational
Heart Failure: registrational readout pending
Entered Phase 3 on partial signal mid-stage evidence. Registrational readout expected around 2027-06-30.
HEAL-CHF (NCT03763136): The trial randomized 20 participants to hPSC-CM therapy or a sham comparator consisting of coronary artery bypass surgery alone, with outcome assessors masked to treatment assignment. Its primary endpoints were clinical safety outcomes, but results are not posted and the small sample limits the strength of the evidence.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
68 competitors in this universe: 8 direct rivals (same mechanism and indication), 0 same-class, 60 same-indication; 17 further along in development.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| HiCM-188 (allogeneic iPSC-Cardiomyocytes): this drug | Phase 3 | Cell therapy | Cardiac cell therapy | ||
| CardiAMP | Phase 3 | Cell therapy | Cardiac cell therapy | ||
| Deramiocel (CAP-1002) | Phase 3 | Cell therapy | Cardiac cell therapy | ||
| ADR-002K | Phase 2 | Cell therapy | Cardiac cell therapy | ||
| HS-001 | Phase 1/2 | Cell therapy | Cardiac cell therapy | ||
| HucMSC Intramyocardial Therapy | Phase 1/2 | Cell therapy | Cardiac cell therapy | ||
| Anhui HygeianCells EE001 | Phase 1 | Biologic (subtype unspecified) | Cardiac cell therapy | ||
| iPSC-CL | Phase 1 | Cell therapy | Cardiac cell therapy | ||
| STM01 | Phase 1 | Cell therapy | Cardiac cell therapy | ||
| Baxdrostat (Baxfendy) | Approved | Small molecule | Aldosterone synthase (CYP11B2) | ||
| Dapagliflozin (Farxiga / Forxiga) | Approved | Small molecule | SGLT2 | ||
| Empagliflozin (Jardiance) | Approved | Small molecule | SGLT2 | ||
| Ferric Carboxymaltose (Injectafer / Ferinject) | Approved | Iron Complex (iv) | Iron repletion | ||
| Ferric Derisomaltose (Monoferric / Monofer) | Approved | Iron Complex (iv) | Iron repletion | ||
| Finerenone (Kerendia) | Approved | Small molecule | Mineralocorticoid receptor | ||
| Furosemide (subcutaneous, scPharmaceuticals) (FUROSCIX) | Approved | Small molecule | NKCC2 |
…and 53 more. Research shows the complete landscape.
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Compare head-to-head
2 further head-to-head pairs are tracked; the rosters on each shared mechanism and indication page list every rival in the race.
Upcoming events
(4 total)
Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.
2026 (1)
November 2026 (1)
What to watch
2027 (1)
June 2027 (1)
What to watch
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.