Asset profile
Elexacaftor / tezacaftor / ivacaftor · Trikafta
Small molecule
Evidence outlook
Approved: Cystic Fibrosis
Regulatory approval supersedes design-level evidence grading; the trials behind approval are preserved below as the drug's evidence history.
How the evidence outlook works ↗
Featured trials
The studies most instrumental to this drug's clinical progression, individually graded on design and result. Pick an indication; Research unlocks the trials, endpoints, key results and grades.
Competitive landscape
7 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 7 same-indication.
| Drug | Stage | Modality | Mechanism | Evidence signal | Reported efficacygraded featured trials |
|---|---|---|---|---|---|
| Elexacaftor / Tezacaftor / Ivacaftor (Trikafta): this drug | Approved | Small molecule | — | ||
| Ivacaftor (Kalydeco) | Approved | Small molecule | — | ||
| Lumacaftor | Approved | Small molecule | CFTR | ||
| Tezacaftor / Ivacaftor (Symdeko) | Approved | Small molecule | — | ||
| Vanzacaftor / Tezacaftor / Deutivacaftor (Alyftrek) | Approved | Small molecule | — | ||
| VX-522 | Phase 1/2 | RNA / oligonucleotide | — | ||
| KB407 | Phase 1 | Gene therapy / editing | — | ||
| VX-828 | Phase 1 | Small molecule | — |
Unlock the full comparison
Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.
Upcoming events
No upcoming readouts on record for this asset.
All registered studies
Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.