Asset profile

Casdatifan

Small molecule

Phase 3Mechanism not established
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Phase 3underway

Evidence outlook · registrational

Clear Cell Renal Cell Carcinoma: registrational readout pending

Its supporting mid-stage evidence has not yet been graded on this platform. Registrational readout expected around 2028-04.

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Competitive landscape

5 competitors in this universe: 0 direct rivals (same mechanism and indication), 0 same-class, 5 same-indication; 1 further along in development.

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DrugStageModalityMechanismEvidence signalReported efficacygraded featured trials
Casdatifan: this drugPhase 3Small molecule—
CabozantinibApprovedSmall moleculeMulti-kinase inhibitor (VEGFR/PDGFR/KIT)
TipifarnibPhase 3Small moleculeFarnesyltransferase
ZanzalintinibPhase 3Small moleculeVEGFR2; MET; AXL; MER; TYRO3
CTX131Phase 1/2Cell therapy—
XmAb819Phase 1Multispecific antibody—
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Research adds each competitor's evidence grade and sourced trial results, aligned per race, so you can see who actually has the data.

Upcoming events

(8 total)

Estimated primary-completion dates from ClinicalTrials.gov. These are registry estimates, never confirmed readout dates; they can move as trials progress.

2027 (3)
January 2027 (1)
Phase 1Clear Cell Renal Cell CarcinomaActive not recruiting
Est. primary completion 2027-01-29 · NCT07000149 · CT.gov ↗
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May 2027 (1)
Phase 1Healthy Participants, Hepatic ImpairmentRecruiting
Est. primary completion 2027-05 · NCT07751250 · CT.gov ↗
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November 2027 (1)
Phase 1/2Clear Cell Renal Cell CarcinomaRecruiting
Est. primary completion 2027-11-02 · NCT07227415 · CT.gov ↗
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2028 (2)
January 2028 (1)
Phase 2Renal Cell Carcinoma, Kidney Cancer, Kidney Neoplasm, Renal CarcinomaRecruiting
Est. primary completion 2028-01-31 · NCT07397611 · CT.gov ↗
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April 2028 (1)
Phase 3Clear Cell Renal Cell CarcinomaRecruiting
Est. primary completion 2028-04 · NCT07011719 · CT.gov ↗
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2029 (2)
March 2029 (1)
Phase 1Clear Cell Renal Cell CarcinomaRecruiting
Est. primary completion 2029-03 · NCT05536141 · CT.gov ↗
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November 2029 (1)
Phase 1/2Advanced Renal Cell Carcinoma (RCC)Recruiting
Est. primary completion 2029-11-28 · NCT07293351 · CT.gov ↗
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2030 (1)
July 2030 (1)
Phase 1Clear Cell Renal Cell CarcinomaRecruiting
Est. primary completion 2030-07-01 · NCT07748988 · CT.gov ↗
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All registered studies

Every ClinicalTrials.gov study of this drug's own program, grouped by indication and phase. Research unlocks the studies themselves: titles, statuses, dates and featured-trial cross-links.

Phase 3 (1)
Phase 2 (1)
Phase 1/2 (2)
Phase 1 (9)