Head-to-head evidence
ICP-490 vs Thalidomide
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Multiple Myeloma
Shared mechanism: Cereblon E3 ubiquitin-ligase · full Multiple Myeloma pipeline
ICP-490
Developed by Beijing InnoCare Pharma Tech Co.
NCT05719701 · Phase 1/2 · status unknown
This is an unblinded, non-randomized dose-finding study with no control arm, and no results have been posted yet, so it cannot currently demonstrate a controlled treatment effect.
Thalidomide
Marketed by Bristol-Myers Squibb
NCT00083551 · Phase 3 · completed
The trial randomly assigned 323 participants to thalidomide and 345 to no thalidomide, but treatment was open-label rather than blinded. Its primary endpoint was the hard clinical outcome of six-year overall survival; although the reported percentages favored thalidomide, statistical significance cannot be determined from the posted registry data.
Next expected readout: August 2027 · NCT00572169 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: ICP-490's landscape · Thalidomide's landscape