Head-to-head evidence
golimumab vs infliximab-dyyb (Zymfentra)
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Ulcerative Colitis
Shared mechanism: TNF-alpha · full Ulcerative Colitis pipeline
golimumab · Simponi
Marketed by Johnson & Johnson and partners
NCT01863771 · Phase 3 · completed
Design meets the 'strong' bar: randomized, double-blind (participant and investigator masked), placebo-controlled, phase 3, with a hard clinical endpoint (Mayo score-based clinical response); the primary comparison was clearly met in the favorable direction (18/32 vs 6/31, non-overlapping 95% CIs).
infliximab-dyyb (Zymfentra)
Marketed by Celltrion
NCT04205643 · Phase 3 · completed
The trial was randomized, quadruple-blind, and placebo-controlled, with 548 participants enrolled and 438 participants included in the reported maintenance analysis. The hard clinical primary endpoint—clinical remission by the modified Mayo score at week 54—was met, with 127 of 294 participants receiving CT-P13 versus 30 of 144 receiving placebo (p<0.0001).
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: golimumab's landscape · infliximab-dyyb (Zymfentra)'s landscape