Head-to-head evidence

EPI-326 vs SH-1028

Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.

Non-Small Cell Lung Cancer

Shared mechanism: EGFR · full Non-Small Cell Lung Cancer pipeline

EPI-326

Developed by EpiBiologics

Phase 1 in Non-Small Cell Lung Cancerbispecific antibody
not yet graded

No graded featured trial for this indication yet; the grade above reflects that absence, not a judgment.

Next expected readout: July 2029 · NCT07462377 (registry estimate)

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SH-1028

Developed by Nanjing Sanhome Pharmaceutical

Phase 3 in Non-Small Cell Lung Cancersmall molecule
Reliable signal

NCT04239833 · Phase 3 · status unknown

In this randomized, double-blind, active-controlled Phase 3 trial in patients with EGFR-mutated non-small-cell lung cancer, SH-1028 significantly extended progression-free survival compared with gefitinib, the standard EGFR-targeted therapy (median 19.3 months vs 9.8 months).

Next expected readout: February 2028 · NCT06080776 (registry estimate)

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The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: EPI-326's landscape · SH-1028's landscape