Head-to-head evidence
CM313 vs Isatuximab
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Multiple Myeloma
Shared mechanism: CD38 · full Multiple Myeloma pipeline
CM313
Developed by Keymed Biosciences
NCT04818372 · Phase 1 · status unknown
This is an early, single-arm, open-label safety and dose-finding study with no randomization or comparator group, so it cannot show whether CM313 works better than another treatment. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.
Isatuximab
Marketed by Sanofi
NCT02990338 · Phase 3 · completed
Participants were randomized 1:1 to isatuximab plus pomalidomide and dexamethasone or pomalidomide and dexamethasone alone, but the study was open-label rather than double-blind. The primary clinical endpoint, progression-free survival, was met: median survival was 11.53 versus 6.47 months, with a hazard ratio of 0.596 and p=0.0005.
Next expected readout: November 2026 · NCT06517017 (registry estimate)
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: CM313's landscape · Isatuximab's landscape