Head-to-head evidence
Baxdrostat vs JX09
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Hypertension
Shared mechanism: Aldosterone synthase (CYP11B2) · full Hypertension pipeline
Baxdrostat · Baxfendy
Marketed by AstraZeneca
NCT06034743 · Phase 3 · completed
The trial randomized 794 participants to baxdrostat or matching placebo and used quadruple masking of participants, care providers, investigators, and outcome assessors. Both prespecified primary blood-pressure endpoints were met at Week 12: the reduction in seated systolic blood pressure was greater with 2 mg and 1 mg baxdrostat than with placebo, with p<0.0001 for each comparison.
Next expected readout: December 2026 · NCT07222917 (registry estimate)
JX09
Developed by Ji Xing Pharmaceuticals (CORXEL)
NCT06183671 · Phase 1 · status unknown
This is a randomized, blinded, placebo-controlled phase 1 study in 92 healthy volunteers testing single and multiple ascending doses of JX09, with safety and tolerability as the primary focus rather than a disease efficacy measure. Results have not been posted.
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: Baxdrostat's landscape · JX09's landscape