Head-to-head evidence
apremilast vs Hemay005
Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.
Psoriasis
Shared mechanism: PDE4 · full Psoriasis pipeline
apremilast · Otezla
Marketed by Amgen
NCT01194219 · Phase 3 · completed
This was a randomized, quadruple-blind, placebo-controlled trial of 844 participants, with 562 assigned to apremilast and 282 to placebo. The primary clinical endpoint was met: PASI-75 response at Week 16 was 33.1% with apremilast versus 5.3% with placebo (p<0.0001).
Next expected readout: October 2026 · NCT07432386 (registry estimate)
Hemay005
Developed by Tianjin Hemay Pharmaceutical
NCT04839328 · Phase 3 · completed
The study randomized 306 participants to Hemay005 or placebo, with participants masked to treatment, and used the clinical PASI75 response as its primary endpoint. Because no comparative results or statistical analysis are posted, the primary endpoint cannot be assessed.
Caveat: this result is taken from a company announcement or a news report of one, not from the trial registry or a peer-reviewed publication. Treat the figures as the sponsor's own statement, not as independently verified evidence.
The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: apremilast's landscape · Hemay005's landscape