Head-to-head evidence

AK138D1 vs Patritumab Deruxtecan

Same mechanism, same race: design-graded trial evidence for both assets, with the grading rationale shown. Grades describe the quality of the evidence, never the merits of either security.

Non-Small Cell Lung Cancer

Shared mechanism: HER3 · full Non-Small Cell Lung Cancer pipeline

AK138D1

Developed by Akeso

Phase 1/2 in Non-Small Cell Lung Cancerantibody-drug conjugate
not yet graded

No graded featured trial for this indication yet; the grade above reflects that absence, not a judgment.

Next expected readout: June 2028 · NCT07623356 (registry estimate)

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Patritumab Deruxtecan

Developed by Daiichi Sankyo and partners

Phase 3 in Non-Small Cell Lung Cancerantibody-drug conjugate
Weak signal

NCT05865990 · Phase 2 · completed

The study used a single-arm, open-label design with no placebo or active comparator, so responses cannot be reliably separated from the natural course of disease or other factors. Registry results were not posted at the time of grading; the key result shown was recovered from the cited external source.

Next expected readout: September 2027 · NCT06172478 (registry estimate)

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The full competitive landscape for each asset (every same-race competitor with aligned evidence, sortable) is on the asset pages: AK138D1's landscape · Patritumab Deruxtecan's landscape